Procedures to Prepare the ADNI Genomic Data for Statistical Analysis
Alzheimer's disease is a cognitive disorder which primarily affects adults over the age of 55. Genetics are known to influence the risk of Alzheimer's disease and could play a role in early detection. The Alzheimer's Disease Neuroimaging Initiative (ADNI) collected information or "genotypes" on genome-wide variation at some 500000 single nucleotide polymorphisms (SNPs), in a case-control study of approximately 800 adults. However, due to technical limitations, some genotype information is missing. Statistical imputation is required to complete the available genotyping information before the data can be analyzed. The work involved in this project will consist of learning and documenting the imputation process and other statistical methods for the ADNI data, and building a robust program to automate the imputation.